DSIP may refer to Delta Sleep-Inducing Peptide

Delta Sleep-Inducing Peptide (DSIP)

A naturally occurring peptide that promotes sleep

First isolated from rabbit brain in 1977

Synthesized in the hypothalamus

Can cross the blood-brain barrier and is absorbed from the gut

Has been shown to induce delta-sleep in rabbits, rats, mice, and humans

Has also been observed to affect neurotransmitter levels, circadian rhythms, and hormonal levels

Low concentrations of DSIP have been observed in patients with schizophrenia and depression

Other effects

DSIP affects neurotransmitter levels in the brain

DSIP affects circadian and locomotor patterns

DSIP affects hormonal levels

DSIP affects psychological performance

DSIP affects the activity of neuropharmacological drugs

DSIP has anticarcinogenic properties

DSIP has geroprotective effects

DSIP has been used to treat withdrawal symptoms from alcohol and opiates

DSIP has been shown to improve motor function in rats after a stroke