MOTS-c is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use. Two other mitochondrial-derived peptides (MDPs) have also been discovered so far, humanin and SHLP1-6, but their possible involvement in human performance enhancement is unknown. According to new research, mitochondrial-derived peptides such as MOTS-c have a role in maintaining mitochondrial function and protecting cells under different stresses1.  It has been shown that exercise causes MOTS-c levels to go up in humans. it has been shown in mice that MOTS-c treatment improves physical performance in mice of all ages and seems to regulate skeletal muscle metabolism and gene expression1